Homozygous form of the Pelger-Huët anomaly.

Neuroblastoma amplified sequence gene is associated with a novel short stature syndrome characterised by optic nerve atrophy and Pelger–Huët anomaly

BACKGROUND Hereditary short stature syndromes are clinically and genetically heterogeneous disorders and the cause have not been fully identified. Yakuts are a population isolated in Asia; they live in the far east of the Russian Federation and have a high prevalence of hereditary short stature syndrome including 3-M syndrome. A novel short stature syndrome in Yakuts is reported here, which is ...

Microsoft Word - AHA274BF

A. Vaya, A. Garcia, Y. Mira, J. Aznar, Departamento de Biopatologia Clínica, Ciudad Sanitaria ‘La Fe’, Avda. Campanar, 21, Valencia-9 (Spain) The Pelger-Huët anomaly is a hereditary disorder of the leukocytes, characterized in its heterozygous manifestation by an incomplete segmentation of the nuclei of the granulocytes [3]. The heterozygous phenocopy of this anomaly (pseudo-Pelger-Huët) has be...

Microsoft Word - AHA127BF

Anomalous cells of the Pelger-Huët type appear mainly in diseases affecting granulopoiesis such as myeloproliferative disorders, aplastic anemia and agranulocytosis [1]. The association of this anomaly with disorders of the lymphatic system is rare and had been described only in 1 patient with chronic lymphocytic leukemia [2]. Recently we have encountered another patient with chronic lymphocyti...

Inherited Disorder: Pelger-Huët Anomaly

Submit Manuscript | http://medcraveonline.com Abbreviations: AML: Acute Myeloid Leukemia; CBC: Complete Blood Count; CML: Chronic Myeloid Leukemia; HIV: Human Immunodeficiency Virus; IFN-g: Interferon Gamma; INM: Inner Nuclear Membrane; LBR: Lamin B Receptor; MDS: Myelodysplastic Syndrome; NE: Nuclear Envelope; ONM: Outer Nuclear Membrane; PHA: Pelger-Huët Anomaly; PHA: PseudoPelger-Huët Anomal...

The Pelger-Huët familial anomaly of leukocytes.